Landry Laboratory

Our research is at the crossroad between cell biology and population genetics. We study the architecture and evolution of gene networks. We are particularly interested in transcriptional networks and protein-protein interaction networks that involve signaling proteins. These are key proteins because they regulate cell fate decisions, responses to environmental perturbations and interactions among individual cells.

Using the budding yeast Saccharomyces cerevisiae and its closely related species as models, we are addressing the following questions:

• How does the complexity of gene networks evolve as a function of gene duplication?
• Which network properties make them robust to genetic and environmental perturbations?
• How does genetic diversity affect the dynamics and structure of gene networks?
• How does the architecture of gene networks diverge among species?

We are using tools such as bioinformatics, functional genetics and genomics, protein-fragment complementation assays (PCA), mass spectrometry and automation tools to answer these questions. Please consult our publication page for more details on our research interests. Our research is supported by the Canadian Institutes of Health Research (CIHR), le Fonds de la Recherche en Santé du Québec (FRSQ), the Canadian Foundation for Innovation (CFI), the Quebec Research Network on Protein Function, Structure and Engineering (PROTEO), the Human Frontier Science Program (HFSP), the Natural Sciences and Engineering Research Council of Canada (NSERC) and Laval University.

Picture credit: Emmanuel D Levy